Which pupil finding is listed as an indication related to naloxone administration?

Which pupil finding is listed as an indication related to naloxone administration?

• A. Mydriasis
• B. Pupillary constriction
• C. Miosis (pinpoint pupils)
• D. Ptosis

Answer: (C)

Pinpoint pupils are a classic sign of opioid effect, making miosis the best indicator for using naloxone in a suspected overdose. Opioids activate mu receptors in the brainstem, increasing parasympathetic tone and causing pupil constriction. Naloxone blocks those receptors and reverses the effects; as reversal occurs, pupils often return toward normal size along with improved breathing and mental status. Dilated pupils (mydriasis) aren’t typical of opioid overdose and suggest other causes, while ptosis isn’t related to opioid effects. The precise phrase “miosis (pinpoint pupils)” captures the hallmark sign that supports naloxone administration.

Pinpoint pupils are a classic sign of opioid effect, making miosis the best indicator for using naloxone in a suspected overdose. Opioids activate mu receptors in the brainstem, increasing parasympathetic tone and causing pupil constriction. Naloxone blocks those receptors and reverses the effects; as reversal occurs, pupils often return toward normal size along with improved breathing and mental status. Dilated pupils (mydriasis) aren’t typical of opioid overdose and suggest other causes, while ptosis isn’t related to opioid effects. The precise phrase “miosis (pinpoint pupils)” captures the hallmark sign that supports naloxone administration.